SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data
نویسندگان
چکیده
We compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences when blind-testing 15 samples. Calibration relation to reference reagent and standard curve obtained by a dilution series reduced inter-laboratory variability ca 10-fold. The harmonisation quantification is vital step towards determining protective therapeutic levels antibodies.
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ژورنال
عنوان ژورنال: Eurosurveillance
سال: 2021
ISSN: ['1025-496X', '1560-7917']
DOI: https://doi.org/10.2807/1560-7917.es.2021.26.27.2100568